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KMID : 0355820190400010001
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Korean Journal of Oral Anatomy
2019 Volume.40 No. 1 p.1 ~ p.8
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Localization of Eruption-Related Molecules in Developing Rat Incisors
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Han Geum-Dong
Shim Hae-Kyoung
Kim Se-Eun
Kang Ji-Hye
Kim Min-Seok
Lee Eun-Joo
Kim Sun-Hun
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Abstract
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A complex and intricate cascades of gene expression is necessary for tooth development, and tooth eruption is one of main events during tooth development. Tooth eruption is considered to be strictly controlled either by signaling or extracellular molecules that are secreted by the tooth germs themselves. There have been numerous reports on the eruption-related molecules; however, there is still a lack of information regarding the preparation of the eruption pathway and the key tissue factors involved. This study aimed to localize the eruption-related molecules such as cyclophilin A (Cyp-A), extracellular matrix metalloproteinase inducer (EMMPRIN), matrix metalloproteinase proteins (MMP-9), receptor activator of nuclear factor kappa-B ligand (RANKL), and osteoprotegerin (OPG) in the developing rat incisors. Immunofluorescence findings revealed that Cyp-A, EMMPRIN, OPG, and RANKL were expressed strongly in the dental lamina epithelium of the rat incisor germs during eruptive movement. OPG was also expressed in the osteoclasts in the apical region. MMP-9, a final tissue resolution molecule, was more widely localized in the area surrounding the erupting incisor. This study suggested that the dental lamina epithelium may play a key role in preparing eruption pathways for the incisor in rats.
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KEYWORD
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Cyp-A, EMMPRIN, OPG, RANKL, MMP, tooth eruption
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